The main concern with the compound is the possibility of androgenic side effects. Usually in male users these side effects will only appear if a user is administering rather large doses of the drug. An individual may encounter the typical side effects of oily skin, acne, exacerbation of male pattern baldness if the condition already exists, and body/facial hair growth. As should be expected with a compound in which dihydrotestosterone plays such a major role, prostate problems are also not uncommon with users. Women should also be aware that virilization symptoms are also a possibility with use of the compound. Deepening of the voice, menstrual irregulation, and other symptoms could all occur 1,3 .
The second most common reason is probably to address a fear that libido might be lost without it. It is true that when added to normal androgen levels, Proviron has an androgenic effect that in many cases improves libido. However, most anabolic steroids also have this same property. In a steroid cycle, adding Proviron accomplishes nothing further. Or in the case of anabolic steroids such as nandrolone ( Deca ) which for other reasons may adversely affect libido, Proviron provides no greater help against that than do various other anabolic steroids .
In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed.  In patients with dysthymia , unipolar , and bipolar depression significant improvement was observed.  In this series of studies, mesterolone lead to a significant decrease in LH and testosterone levels. In another study, 100 mg mesterolone cypionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.