DDE has been shown to be toxic to rats at mg/kg.  DDE and its parent, DDT, are reproductive toxicants for certain birds species, and major reasons for the decline of the bald eagle ,  brown pelican  peregrine falcon , and osprey .  These compounds cause egg shell thinning in susceptible species, which leads to the birds’ crushing their eggs instead of incubating them, due to the latter’s lack of resistance.  Birds of prey , waterfowl , and song birds are more susceptible to eggshell thinning than chickens and related species , and DDE appears to be more potent than DDT. 
Results wise, users should expect extreme strength increases and weight gain in a relatively short 2-4 week period. Weight gain upwards of 20lbs in 4 weeks is not unheard of with this incredibly potent compound. Although subcutaneous water gain would be minimal, intramuscular water retention should be expected. This is due to inhibition of 11b-hydroxylase and build-up of mineralcorticoids which encourage salt and water retention within the muscles. The most obvious physical effects will be improved vascularity, aggressive muscular pumps, and oily skin.
While methyldrostanolone can stack well with most other steroids, it should never be stacked with another methylated (17aa) steroid.