The cooling zone temperature in these cases can be established beforehand with the aid of a melting point measuring instrument equipped with a opticaly microscope (. Mettler's melting/boiling point meter Model FP-80 or FP-82HT equipped with a polarizing microscope), a differential scanning calorimeter (DSC) or the like. Thus, in the case of a melting point measuring instrument equipped with a opticaly microscope, the method can be used which comprises melting the medicinal substance on a slide glass, cooling it to find the temperature at which metastable crystals are formed and using the particular temperature as the cooling zone temperature.
However, in December 2004 the United States the 14-member Food and Drug Administration (FDA) advisory committee, plus voting consultants, for Reproductive Health Drugs unanimously rejected Procter and Gamble's fast-track request for Intrinsa citing concerns about off-label use . In Canada, post-menopausal women have been able to obtain government-approved testosterone treatment since 2002. In Australia, post-menopausal women can use Organon testosterone implants which have to be surgically inserted and last from three to six months. 
Some bodybuilders and athletes use trenbolone for its muscle-building and otherwise performance-enhancing effects. [ citation needed ] Such use is illegal in the United States and many other countries. The DEA classifies trenbolone as a Schedule III controlled substance under the Controlled Substances Act .  Trenbolone is classified as a Schedule 4 drug in Canada  and a class C drug with no penalty for personal use or possession in the United Kingdom .  Use or possession of steroids without a prescription is a crime in Australia .  The infamous "duchess" cocktail administered to Russian athletes at the Sochi Winter Olympics consisted of oxandrolone , metenolone , and trenbolone.